Molecular Genetics

The University of Glasgow has a longstanding reputation as a centre for world-class research and teaching in genetics.




Overend, G., Cabrero, P., Halberg, K. A.,, Ranford-Cartwright, L. C., Woods, D., Davies, S. A., Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi: 10.1016/j.ibmb.2015.05.007)

Terhzaz, S., Cabrero, P., Brinzer, R. A., Halberg, K. A., Dow, J. A.T., Davies, S.-A. (2015) A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance Insect Biochemistry and Molecular Biology, 67, pp. 38-46. (doi: 10.1016/j.ibmb.2015.06.002)

Brinzer, R., Henderson, L., Marchiondo, A. A., Woods, D. J., Davies, S., Dow, J. A. T. (2015) Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival Insect Biochemistry and Molecular Biology, 67, pp. 74-86. (doi: 10.1016/j.ibmb.2015.09.009)

Dow, J. A. T., Davies, S. A. (2015) What is an epitheliome, anyway? Insect Biochemistry and Molecular Biology, 67, pp. 1. (doi: 10.1016/j.ibmb.2015.10.013)

Kaiserli, E., Páldi, K., O’Donnell, L., Batalov, O., Pedmale, U. V., Nusinow, D. A., Kay, S. A., Chory, J. (2015) Integration of light and photoperiodic signaling in transcriptional nuclear foci Developmental Cell, 35, pp. 311-321. (doi: 10.1016/j.devcel.2015.10.008)

Alles, J., Hasler, D., Kazmi, S. M. A., Tesson, M., Hamilton, A., Schlegel, L., Marx, S., Eichner, N., Reinhardt, R., Meister, G., Wilson, J. B., Grässer, F. A. (2015) Epstein-Barr virus EBER transcripts affect miRNA-mediated regulation of specific targets and are processed to small RNA species Non-Coding RNA, 1, pp. 170-191. (doi: 10.3390/ncrna1030170)

Jones, M. A., Hu, W., Litthauer, S., Lagarias, J. C., Harmer, S. L. (2015) A constitutively active allele of phytochrome B maintains circadian robustness in the absence of light. Plant Physiology, 169, pp. 814-825. (doi: 10.1104/pp.15.00782)

Litthauer, S., Battle, M. W., Lawson, T., Jones, M. A. (2015) Phototropins maintain robust circadian oscillation of PSII operating efficiency under blue light Plant Journal, 83, pp. 1034-1045. (doi: 10.1111/tpj.12947)

Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G., Davies, S. A., Romero, M. F., Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities Proceedings of the National Academy of Sciences of the United States of America, 112, pp. 11720-11725. (doi: 10.1073/pnas.1508031112)

Bowyer, J., Zhao, J., Rosser, S., Colloms, S., Bates, D. (2015) Development and experimental validation of a mechanistic model of in vitro DNA recombination (doi: 10.1109/EMBC.2015.7318519)

Grefen, C., Karnik, R., Larson, E., Lefoulon, C., Wang, Y., Waghmare, S., Zhang, B., Hills, A., Blatt, M. R. (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion Nature Plants, 1, (doi: 10.1038/nplants.2015.108)

Amtmann, A., Ma, H., Wagner, D. (2015) Chromatin and epigenetics Plant Physiology, 168, pp. 1185-1188. (doi: 10.1104/pp.15.01023)

Dutta, D., Dobson, A. J., Houtz, P. L., Gläßer, C., Revah, J., Korzelius, J., Patel, P. H., Edgar, B. A., Buchon, N. (2015) Regional cell-specific transcriptome mapping reveals regulatory complexity in the adult Drosophila midgut Cell Reports, 12, pp. 346-358. (doi: 10.1016/j.celrep.2015.06.009)

Qi, Q., Downer, M.K., Kilpeläinen, T.O., Taal, H. R., Barton, S.J., Ntalla, I., Standl, M., Boraska, V., Huikari, V., Kiefte-de Jong, J.C., Körner, A., Lakka, T.A., Liu, G., Magnusson, J., Okuda, M., Raitakari, O., Richmond, R., Scott, R.A., Bailey, M.E.S., Scheuermann, K., Holloway, J.W., Inskip, H., Isasi, C.R., Mossavar-Rahmani, Y., Jaddoe, V.W.V., Laitinen, J., Lindi, V., Melén, E., Pitsiladis, Y., Pitkänen, N., Snieder, H., Heinrich, J., Timpson, N.J., Wang, T., Yuji, H., Zeggini, E., Dedoussis, G.V., Kaplan, C., Wylie-Rosett, J., Loos, J.F., Hu, F.B., Qi, L. (2015) Dietary intake, FTOGenetic variants, and adiposity: a combined analysis of over 16,000 children and adolescents Diabetes, 64, pp. 2467-2476. (doi: 10.2337/db14-1629)

Gao, X., Wilson, J.B. (2015) LMP1: Chronic Inflammation and Carcinogenesis

de la Fila, A. G., Bain, S. A., Ross, L. (2015) Haplodiploidy and the reproductive ecology of arthropods Current Opinion in Insect Science, 9, pp. 36-43. (doi: 10.1016/j.cois.2015.04.018)

Zhang, B., Karnik, R., Wang, Y., Wallmeroth, N., Blatt, M. R., Grefen, C. (2015) The arabidopsis R-SNARE VAMP721 interacts with KAT1 and KC1 K+ channels to moderate K+ current at the plasma membrane Plant Cell, 27, pp. 1697-1717. (doi: 10.1105/tpc.15.00305)

van Engelen, B., The OPTIMISTIC Consortium, , , (2015) Cognitive behaviour therapy plus aerobic exercise training to increase activity in patients with myotonic dystrophy type 1 (DM1) compared to usual care (OPTIMISTIC): study protocol for randomised controlled trial Trials, 16, (doi: 10.1186/s13063-015-0737-7)

Bühlmann, M., Walrad, P., Rico, E., Ivens, A., Capewell, P., Naguleswaran, A., Roditi, I., Matthews, K. R. (2015) NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway Nucleic Acids Research, 43, pp. 4491-4504. (doi: 10.1093/nar/gkv330)

Dobson, A. J., Chaston, J. M., Newell, P. D., Donahue, L., Hermann, S. L., Sannino, D. R., Westmiller, S., Wong, A. C.-N., Clark, A. G., Lazzaro, B. P., Douglas, A. E. (2015) Corrigendum: Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster Nature Communications, 6, (doi: 10.1038/ncomms8296)

Papanatsiou, M., Scuffi, D., Blatt, M. R., Garia-Mata, C. (2015) Hydrogen sulphide regulates inward-rectifying K+ channels in conjunction with stomatal closure Plant Physiology, 168, pp. 29-35. (doi: 10.1104/pp.114.256057)

Morales, F., Vásquez, M., Cuenca, P., Campos, D., Santamaría, C., del Valle, G., Brian, R., Sittenfeld, M., Monckton, D. G. (2015) Parental age effects, but no evidence for an intrauterine effect in the transmission of myotonic dystrophy type 1 European Journal of Human Genetics, 23, pp. 646-653. (doi: 10.1038/ejhg.2014.138)

Finlay, C., McVey, M., Paschke, B. (2015) A Pre-Entry Distance Course on Moodle: Articulating Course Expectations, Aiming to Impact on Access and Student Confidence

DeLeeuw, J., Weir, J., Copsey, D., Roden, C., Deeley, S., Huston, E., McVey, M., Finlay, C. (2015) Developing Graduate Attributes and Improving Student Employability Through Work-based Learning: Opportunities, Successes and Challenges

Larson, E., Fyfe, I., Morton, A. J., Monckton, D. G. (2015) Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice Neurobiology of Disease, 76, pp. 98-111. (doi: 10.1016/j.nbd.2015.01.004)

Sykes, A., Morrison, D., Gray, J. (2015) Half as Much but Twice as Good: LEAF and New Directions in Assessment and Feedback

Halberg, K., Terhzaz, S., Cabrero, P., Davies, S. A., Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function Nature Communications, 6, (doi: 10.1038/ncomms7800)

Terhzaz, S., Teets, N., Cabrero, P., Henderson, L., Richie, M. G., Nachman, R. J., Dow, J. A. T., Denlinger, D. L., Davies, S.-A. (2015) The insect capa neuropeptides impact desiccation and cold tolerance Proceedings of the National Academy of Sciences of the United States of America, 112, pp. 2882-2887. (doi: 10.1073/pnas.1501518112)

Kaiserli, E., Chory, J. (2015) The role of phytochromes in triggering plant developmental transitions John Wiley and Sons Ltd

Karnik, R., Zhang, B., Waghmare, S., Aderhold, C., Grefen, C., Blatt, M. R. (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane Plant Cell, 27, pp. 675-694. (doi: 10.1105/tpc.114.134429)

Dobson, A. J., Chaston, J. M., Newell, P. D., Donahue, L., Hermann, S. L., Sannino, D. R., Westmiller, S., Wong, A. C.-N., Clark, A. G., Lazzaro, B. P., Douglas, A. E. (2015) Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster Nature Communications, 6, (doi: 10.1038/ncomms7312)

Finlay, C. (2015) Does Size Matter? Biological Sciences Review, 27, pp. 2-6.

Capewell, P., Cooper, A., Clucas, C., Weir, W., MacLeod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome Parasitology, 142, pp. S108-S119. (doi: 10.1017/S0031182014000602)

Heilmann, M., Christie, J. M., Kennis, J. T.M., Jenkins, G. I., Mathes, T. (2015) Photoinduced transformation of UVR8 monitored by vibrational and fluorescence spectroscopy Photochemical and Photobiological Sciences, 14, pp. 252-257. (doi: 10.1039/c4pp00246f)

McVey, M., Finlay, C. (2015) Assessment Designed Around Graduate Attributes: Making Best Use of Available Technology to Foster Student Interaction and Support the Individual

Minas, K., Karunakaran, E., Bond, T., Gandy, C., Honsbein, A., Madsen, M., Amezaga, J., Amtmann, A., Templeton, M.R., Biggs, C.A., Lawton, L. (2015) Biodesalination: an emerging technology for targeted removal of Na+and Cl−from seawater by cyanobacteria Desalination and Water Treatment, 55, pp. 2647-2668. (doi: 10.1080/19443994.2014.940647)

Capewell, P., Cooper, A., Clucas, C., Weir, W., Vaikkinen, H., Morrison, L., Tait, A., MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes Methods in Molecular Biology, 1201, pp. 91-107. (doi: 10.1007/978-1-4939-1438-8_5)

Gadalla, K. K. E., Ross, P. D., Hector, R. D., Bahey, N. G., Bailey, M. E.S., Cobb, S. R. (2015) Gene therapy for Rett syndrome: prospects and challenges Future Neurology, 10, pp. 467-484. (doi: 10.2217/fnl.15.29)

Olorunniji, F. J., McPherson, A. L., Pavlou, H. J., McIlwraith, M. J., Brazier, J. A., Cosstick, R., Stark, W. M. (2015) Nicked-site substrates for a serine recombinase reveal enzyme–DNA communications and an essential tethering role of covalent enzyme–DNA linkages Nucleic Acids Research, (doi: 10.1093/nar/gkv521)

Wardle, S. L., Bailey, M. E., Kilikevicius, A., Malkova, D., Wilson, R. H., Venckunas, T., Moran, C. (2015) Plasma microRNA levels differ between endurance and strength athletes PLoS ONE, 10, (doi: 10.1371/journal.pone.0122107)

Mathes, T., Heilmann, M., Pandit, A., Zhu, J., Ravensbergen, J., Kloz, M., Fu, Y., Smith, B.O., Christie, J.M., Jenkins, G.I., Kennis, J.T.M. (2015) Proton-coupled electron transfer constitutes the photoactivation mechanism of the plant photoreceptor UVR8 Journal of the American Chemical Society, 137, pp. 8113-8120. (doi: 10.1021/jacs.5b01177)

Ulm, R., Jenkins, G. (2015) Q&A: How do plants sense and respond to UV-B radiation? BMC Biology, 13, (doi: 10.1186/s12915-015-0156-y)

Suárez, M. B., Alonso-Nuñez, M. L., del Rey, F., McInerny, C. J., Vázquez de Aldana, C. R. (2015) Regulation of Ace2-dependent genes requires components of the PBF complex in schizosaccharomyces pombe Cell Cycle, 14, pp. 3124-3137. (doi: 10.1080/15384101.2015.1078035)

Ji, H., Wang, Y., Cloix, C., Li, K., Jenkins, G. I., Wang, S., Shang, Z., Shi, Y., Yang, S., Li, X. (2015) The arabidopsis RCC1 family protein TCF1 regulates freezing tolerance and cold acclimation through modulating lignin biosynthesis PLoS Genetics, 11, (doi: 10.1371/journal.pgen.1005471)

Stark, W. M. (2015) The serine recombinases ASM Press


Bhutta, M. S., McInerny, C. J., Gould, G. W. (2014) ESCRT function in cytokinesis: location, dynamics and regulation by mitotic kinases International Journal of Molecular Sciences, 15, pp. 21723-21739. (doi: 10.3390/ijms151221723)

Hussain, M., Gatherer, D., Wilson, J. B. (2014) Modelling the structure of full-length Epstein-Barr virus nuclear antigen 1 Virus Genes, 49, pp. 358-372. (doi: 10.1007/s11262-014-1101-9)

Jenkins, G. I. (2014) Structure and function of the UV-B photoreceptor UVR8 Current Opinion in Structural Biology, 29, pp. 52-57. (doi: 10.1016/

Gadalla, K. K.E., Ross, P. D., Riddell, J. S., Bailey, M. E.S., Cobb, S. R. (2014) Gait analysis in a Mecp2 knockout mouse model of Rett syndrome reveals early-onset and progressive motor deficits PLoS ONE, 9, (doi: 10.1371/journal.pone.0112889)

Newell, P. D., Chaston, J. M., Wang, Y., Winans, N. J., Sannino, D. R., Wong, A. C.N., Dobson, A. J., Kagle, J., Douglas, A. E. (2014) In vivo function and comparative genomic analyses of the Drosophila gut microbiota identify candidate symbiosis factors. Frontiers in Microbiology, 5, (doi: 10.3389/fmicb.2014.00576)

Bhutta, M. S., Roy, B., Gould, G. W., McInerny, C. J. (2014) A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe PLoS ONE, 9, pp. e111789. (doi: 10.1371/journal.pone.0111789)

Lefoulon, C., Karnik, R., Honsbein, A., Gutla, P. V., Grefen, C., Riedelsberger, J., Poblete, T., Dreyer, I., Gonzalez, W., Blatt, M. R. (2014) Voltage-sensor transitions of the inward-rectifying K+ channel KAT1 indicate a latching mechanism biased by hydration within the voltage sensor Plant Physiology, 166, pp. 960-975. (doi: 10.1104/pp.114.244319)

Cabrero, P., Terhzaz, S., Romero, M. F., Davies, S. A., Blumenthal, E. M., Dow, J. A. T. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 14301-14306. (doi: 10.1073/pnas.1412706111)

Evans, S., Burgess, K. E.V., Gray, J. V. (2014) Recovery from Rapamycin: drug-insensitive activity of yeast target of rapamycin complex 1 (torc1) supports residual proliferation that dilutes rapamycin among progeny cells Journal of Biological Chemistry, 289, pp. 26554-26565. (doi: 10.1074/jbc.M114.589754)

Dobson, A. J., Purves, J., Rolff, J. (2014) Increased survival of experimentally evolved antimicrobial peptide-resistant Staphylococcus aureus in an animal host. Evolutionary Applications, 7, pp. 905-912. (doi: 10.1111/eva.12184)

Hayes, S., Velanis, C. N., Jenkins, G. I., Franklin, K. A. (2014) UV-B detected by the UVR8 photoreceptor antagonizes auxin signaling and plant shade avoidance Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 11894-11899. (doi: 10.1073/pnas.1403052111)

Gray, J. V. (2014) Case study 15.2: supporting a large undergraduate class using an asynchronous online forum Routledge

Hachez, C., Laloux, T., Reinhardt, H., Cavez, D., Degand, H., Grefen, C., De Rycke, R., Inze, D., Blatt, M. R., Russinova, E., Chaumont, F. (2014) Arabidopsis SNAREs SYP61 and SYP121 coordinate the trafficking of plasma membrane aquaporin PIP2;7 to modulate the cell membrane water permeability Plant Cell, 26, pp. 3132-3147. (doi: 10.1105/tpc.114.127159)

Fogg, P. C.M., Colloms, S., Rosser, S., Stark, M., Smith, M. C.M. (2014) New applications for phage integrases Journal of Molecular Biology, 426, pp. 2703-2716. (doi: 10.1016/j.jmb.2014.05.014)

Gomes-Pereira, M., Hilley, J. D.,, Morales Montero, F., Adam, B., James, H. E., Monckton, D. G. (2014) Disease-associated CAG•CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion Nucleic Acids Research, 42, pp. 7047-7056. (doi: 10.1093/nar/gku285)

Wong, A. C.-N., Dobson, A. J., Douglas, A. E. (2014) Gut microbiota dictates the metabolic response of Drosophila to diet Journal of Experimental Biology, 217, pp. 1894-1901. (doi: 10.1242/jeb.101725)

Coward, K., Gray, J. V. (2014) Audit of Practical Work Undertaken by Undergraduate Bioscience Students Across the UK Higher Education Sector

Blatt, M. R., Wang, Y., Leonhardt, N., Hills, A. (2014) Exploring emergent properties in cellular homeostasis using OnGuard to model K+ and other ion transport in guard cells Journal of Plant Physiology, 171, pp. 770-778. (doi: 10.1016/j.jplph.2013.09.014)

Benito, B., Haro, R., Amtmann, A., Cuin, T. A., Dreyer, I. (2014) The twins K+ and Na+ in plants Journal of Plant Physiology, 171, pp. 723-731. (doi: 10.1016/j.jplph.2013.10.014)

Finlay, C., McVey, M., Paschke, B., Keenan, D., Stewart, K. (2014) Distance Learning Courses: A first attempt with perspectives on the development and day-to-day running

McVey, M., Finlay, C. (2014) Student-led Development of Biology Lab Report Writing, Poster Presentation

Eisenach, C., Papanatsiou, M., Hillert, E.-K., Blatt, M. R. (2014) Clustering of the K+ channel GORK of Arabidopsis parallels its gating by extracellular K+ Plant Journal, 78, pp. 203-214. (doi: 10.1111/tpj.12471)

Kellermeier, F., Armengaud, P., Seditas, T. J., Danku, J., Salt, D. E., Amtmann, A. (2014) Analysis of the root system architecture of Arabidopsis provides a quantitative readout of crosstalk between nutritional signals Plant Cell, 26, pp. 1480-1490. (doi: 10.1105/tpc.113.122101)

Amezaga, J. M., Amtmann, A., Biggs, C. A., Bond, T., Gandy, C. J., Honsbein, A., Karunakaran, E., Lawton, L., KonstantinosMadsen, M. A., Minas, K., Templeton, M. R. (2014) Biodesalination: a case study for applications of photosynthetic bacteria in water treatment Plant Physiology, 164, pp. 1661-1676. (doi: 10.1104/pp.113.233973)

Blatt, M. R., Chaumont, F., Farquhar, G. (2014) Focus on water Plant Physiology, 164, pp. 1553-1555. (doi: 10.1104/pp.114.900484)

Lawson, T., Blatt, M. R. (2014) Stomatal size, speed, and responsiveness impact on photosynthesis and water use efficiency Plant Physiology, 164, pp. 1556-1570. (doi: 10.1104/pp.114.237107)

Wang, Y., Hills, A., Blatt, M. (2014) Systems analysis of guard cell membrane transport for enhanced stomatal dynamics and water use efficiency Plant Physiology, 164, pp. 1593-1599. (doi: 10.1104/pp.113.233403)

Tossi, V., Lamattina, L., Jenkins, G. I., Cassia, R. O. (2014) Ultraviolet-B-induced Sstomatal closure in arabidopsis is regulated by the UV RESISTANCE LOCUS8 photoreceptor in a nitric oxide-dependent mechanism Plant Physiology, 164, pp. 2220-2230. (doi: 10.1104/pp.113.231753)

Terhzaz, S., Overend, G., Sebastian, S., Dow, J. A.T., Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling Peptides, 53, pp. 218-224. (doi: 10.1016/j.peptides.2013.08.004)

Gehl, B., Lee, C. P., Bota, P., Blatt, M. R., Sweetlove, L. J. (2014) An arabidopsis stomatin-like protein affects mitochondrial respiratory supercomplex organization Plant Physiology, 164, pp. 1389-1400. (doi: 10.1104/pp.113.230383)

Lee, C.-W., Antoniou-Kourounioti, R., Wu, J. C.S., Murchie, E., Maroto-Valer, M., Jensen, O., Huang, C. W., Ruban, A. (2014) Photocatalytic conversion of CO2 to hydrocarbons by light-harvesting complex assisted Rh-doped TiO2 photocatalyst Journal of CO2 Utilization, 5, pp. 33-40. (doi: 10.1016/j.jcou.2013.12.002)

Colloms, S.D., Merrick, C.A., Olorunniji, F.J., Stark, W.M., Smith, M.C.M., Osbourn, A., Keasling, J.D., Rosser, S.J. (2014) Rapid metabolic pathway assembly and modification using serine integrase site-specific recombination Nucleic Acids Research, 42, pp. e23. (doi: 10.1093/nar/gkt1101)

Davies, S.A., Cabrero, P., Overend, G., Aitchison, L., Sebastian, S., Terhzaz, S., Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance Journal of Experimental Biology, 217, pp. 119-128. (doi: 10.1242/jeb.090571)

Dow, J.A.T. (2014) Stress Journal of Experimental Biology, 217, pp. 5. (doi: 10.1242/jeb.099606)

Jenkins, G. I. (2014) The UV-B photoreceptor UVR8: from structure to physiology Plant Cell, 26, pp. 21-37. (doi: 10.1105/tpc.113.119446)

Christie, J., Blatt, M. (2014) Plant physiology sees the light Plant Physiology, 164, pp. 12. (doi: 10.1104/pp.113.900477)

Blatt, M. R., Grefen, C. (2014) Applications of fluorescent marker proteins in plant cell biology Humana Press

(2014) Campbell Biology, Custom Textbook, University of Glasgow

Finlay, C., Gillespie, A., McVey, M., Reid, I., Scott, P., Tatner, M., Tierney, A. (2014) Electronic Submission and Audio Feedback: Student and Staff Impressions

Pickrell, W. O., Lawrence, S., Eligar, V., Walters, R., Quaderi, S., Walker, A., Capewell, P., Clucas, C., Vincent, A., Checchi, F., MacLeod, A., Brown, M. (2014) Human African Trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical disease? PLoS Neglected Tropical Diseases, 8, (doi: 10.1371/journal.pntd.0003349)

Ciosi, M., Masiga, D. K., Turner, C. M.R. (2014) Laboratory colonisation and genetic bottlenecks in the tsetse fly Glossina pallidipes PLoS Neglected Tropical Diseases, 8, pp. e2697. (doi: 10.1371/journal.pntd.0002697)


Hirata, T., Cabrero, P., Berkholz, D.S., Bondeson, D.P., Ritman, E.L., Thompson, J.R., Dow, J.A.T., Romero, M.F. (2012) In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis American Journal of Physiology: Renal Physiology, 303, pp. F1555-F1562. (doi: 10.1152/ajprenal.00074.2012)

Dobson, A. J., Johnston, P. R., Vilcinskas, A., Rolff, J. (2012) Identification of immunological expressed sequence tags in the mealworm beetle Tenebrio molitor Journal of Insect Physiology, 58, pp. 1556-1561. (doi: 10.1016/j.jinsphys.2012.09.009)

Wang, Y., Papanatsiou, M., Eisenach, C., Karnik, R., Williams, M., Hills, A., Lew, V.L., Blatt, M.R. (2012) Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration Plant Physiology, 160, pp. 1956-1967. (doi: 10.1104/pp.112.207704)

Davey, M.P., Susanti, N.I., Wargent, J.J., Findlay, J.E., Quick, W.P., Paul, N.D., Jenkins, G.I. (2012) The UV-B photoreceptor UVR8 promotes photosynthetic efficiency in Arabidopsis thaliana exposed to elevated levels of UV-B Photosynthesis Research, 114, pp. 121-131. (doi: 10.1007/s11120-012-9785-y)

Olorunniji, F. J., Buck, D. E., Colloms, S. D., McEwan, A. R., Smith, M. C. M., Stark, W. M., Rosser, S. J. (2012) Gated rotation mechanism of site-specific recombination by ϕC31 integrase Proceedings of the National Academy of Sciences of the United States of America, 109, pp. 19661-19666. (doi: 10.1073/pnas.1210964109)

Grefen, C., Blatt, M.R. (2012) A 2in1 cloning system enables ratiometric bimolecular fluorescence complementation (rBiFC) BioTechniques, 53, (doi: 10.2144/000113941)

Prorocic, M.M., Wenlong, D., Olorunniji, F.J., Akopian, A., Schloetel, J.-G., Hannigan, A., McPherson, A.L., Stark, W.M. (2012) Zinc-finger recombinase activities in vitro Nucleic Acids Research, 39, pp. 9316-9328. (doi: 10.1093/nar/gkr652)

Cloix, C., Kaiserli, E., Heilmann, M., Baxter, K.J., Brown, B.A., O'Hara, A., Smith, B.O., Christie, J.M., Jenkins, G.I. (2012) C-terminal region of the UV-B photoreceptor UVR8 initiates signaling through interaction with the COP1 protein Proceedings of the National Academy of Sciences of the United States of America, 109, pp. 16366-16370. (doi: 10.1073/pnas.1210898109)

Jones, M. A., Williams, B. A., McNicol, J., Simpson, C. G., Brown, J. W.S., Harmer, S. L. (2012) Mutation of Arabidopsis SPLICEOSOMAL TIMEKEEPER LOCUS1 causes circadian clock defects Plant Cell, 24, pp. 4066-4082. (doi: 10.1105/tpc.112.104828)

McVey, M., Finlay, C., Tierney, A. (2012) Moodle Lessons as Pre and Post Lab Exercises in Level 1 Biology Labs

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Finlay, C. (2011) Review: Chemistry of the Solar System by Katharina Lodders and Bruce Fegley, Jr Reviews: HEA Guide to Publications in the Physical Sciences, 22, pp. 10-10.

Finlay, C. (2011) Review: Genome Duplication: Concepts, Mechanisms, Evolution and Disease by Melvin L DePamphilis and Stephen D Bell Reviews - HEA Guide to Publications in the Physical Sciences, 22, pp. 27.

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Gray, J.V., Krause, S.A. (2009) Synthetic genetic interactions: allele dependence, uses, and conservation Advances in Genetics, 66, pp. 61-84. (doi: 10.1016/S0065-2660(09)66003-X)

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Gajdanowicz, P., Garcia-Mata, C., Gonzalez, W., Morales-Navarro, S., Sharma, T., González-Nilo, F.D., Gutowicz, J., Mueller-Roeber, B., Blatt, M., Dreyer, I. (2009) Distinct roles of the last transmembrane domain in controlling Arabidopsis K(+)channel activity New Phytologist, 182, pp. 380-391. (doi: 10.1111/j.1469-8137.2008.02749.x)

Amtmann, A., Armengaud, P. (2009) Effects of N,P,K and S on metabolism: new knowledge gained from multi-level analysis Current Opinion in Plant Biology, 12, pp. 275-283. (doi: 10.1016/j.pbi.2009.04.014)

Volkov, V., Boscari, A., Clement, M., Miller, A.J., Amtmann, A., Fricke, W. (2009) Electrophysiological characterization of pathways for K+uptake into growing and non-growing leaf cells of barley Plant, Cell and Environment, 32, pp. 1778-1790. (doi: 10.1111/j.1365-3040.2009.02034.x)

Spaans, F., Faber, C.G., Smeets, H.J.M., Hofman, P.A.M., Braida, C., Monckton, D.G., de Die-Smulders, C.E.M. (2009) Encephalopathic attacks in a family co-segregating myotonic dystrophy type 1, an intermediate Charcot-Marie-Tooth neuropathy and early hearing loss Journal of Neurology, Neurosurgery and Psychiatry, 80, pp. 1029-1412. (doi: 10.1136/jnnp.2008.170126)

Morrison, A. W., Bailey, M.E.S., Morrison, G. A. J. (2009) Familial Ménière's disease: clinical and genetic aspects Journal of Laryngology and Otology, 123, pp. 29-37. (doi: 10.1017/S0022215108002788)

Favory, J.-J., Stec, A., Gruber, H., Rizzini, L., Oravecz, A., Funk, M., Albert, A., Cloix, C., Jenkins, G.I., Oakeley, E.J., Seidlitz, H.K., Nagy, F., Ulm, R. (2009) Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis EMBO Journal, 28, pp. 591-601. (doi: 10.1038/emboj.2009.4)

Amtmann, A., Leigh, R. (2009) Ion homeostasis Springer

Amtmann, A. (2009) Learning from evolution: Thellungiella generates new knowledge on essential and critical components of abiotic stress tolerance in plants Molecular Plant, 2, pp. 3-12. (doi: 10.1093/mp/ssn094)

Higham, C., Wilcox, D., Haydon, D., Cobbold, C., Monckton, D. (2009) Modelling dynamic DNA in mytonic dystrophy

Pattison, R. J., Amtmann, A. (2009) N-glycan production in the endoplasmic reticulum of plants Trends in Plant Science, 14, pp. 92-99. (doi: 10.1016/j.tplants.2008.11.008)

O'Kane, D., Finlay, C., Mooney, A. (2009) New opportunities for disadvantaged pupils: the step-up programme Routledge

Thompson, R., Schoser, B., Monckton, D.G., Blonsky, K., Lochmüller, H. (2009) Patient registries and trial readiness in myotonic dystrophy – TREAT-NMD/Marigold international workshop report Neuromuscular Disorders, 19, pp. 860. (doi: 10.1016/j.nmd.2009.08.009)

Boscari, A., Clement, M., Volkov, V., Golldack, D., Hybiak, J., Miller, A.J., Amtmann, A., Fricke, W. (2009) Potassium channels in barley: cloning, functional characterization and expression analyses in relation to leaf growth and development Plant, Cell and Environment, 32, pp. 1761-1777. (doi: 10.1111/j.1365-3040.2009.02033.x)

Rowland, S.J., Boocock, M.R., MacPherson, A.L., Mouw, K.W., Rice, P.A., Stark, M.S. (2009) Regulatory mutations in Sin recombinase support a structure-based model of the synaptosome Molecular Microbiology, 74, pp. 282-298. (doi: 10.1111/j.1365-2958.2009.06756.x)

Finlay, C. (2009) Review of: Student Engagement in Higher Education: theoretical perspectives and practical approaches for diverse publications HEA

Jenkins, G.I. (2009) Signal transduction in responses to UV-B radiation Annual Review of Plant Biology, 60, pp. 407-431. (doi: 10.1146/annurev.arplant.59.032607.092953)

Dreyer, I., Blatt, M.R. (2009) What makes a gate? The ins and outs of Kv-like K+ channels in plants Trends in Plant Science, 14, pp. 383-390. (doi: 10.1016/j.tplants.2009.04.001)


James, A.B., Monreal, J.A., Nimmo, G.A., Kelly, C.L., Herzyk, P., Jenkins, G.I., Nimmo, H.G. (2008) The circadian clock in Arabidopsis roots is a simplified slave version of the clock in shoots Science, 322, pp. 1832-1835. (doi: 10.1126/science.1161403)

Chapman, S., Faulkner, C., Kaiserli, E., Garcia-Mata, C., Savenkov, E.I., Roberts, A.G., Oparka, K.J., Christie, J.M. (2008) The photoreversible fluorescent protein iLOV outperforms GFP as a reporter of plant virus infection Proceedings of the National Academy of Sciences of the United States of America, 105, pp. 20038-20043. (doi: 10.1073/pnas.0807551105)

Chen, Z.-H., Jenkins, G.I., Nimmo, H.G. (2008) Identification of an F box protein that negatively regulates Pi starvation responses Plant and Cell Physiology, 49, pp. 1902-1906. (doi: 10.1093/pcp/pcn157)

Grefen, C., Blatt, M.R. (2008) SNAREs-molecular governors in signalling and development Current Opinion in Plant Biology, 11, pp. 600-609. (doi: 10.1016/j.pbi.2008.08.006)

Olorunniji, F.J., He, J., Wenwieser, S.V.C.T., Boocock, M.R., Stark, W.M. (2008) Synapsis and catalysis by activated Tn3 resolvase mutants Nucleic Acids Research, 36, pp. 7181-7191. (doi: 10.1093/nar/gkn885)

Chen, Z.-H., Jenkins, G.I., Nimmo, H.G. (2008) pH and carbon supply control the expression of phosphoenolpyruvate carboxylase kinase genes in Arabidopsis thaliana Plant, Cell and Environment, 31, pp. 1844-1850. (doi: 10.1111/j.1365-3040.2008.01885.x)

McLean, A., Tsimbouri, P., Wilson, J.B. (2008) Massive Overexpression of Chitnase3-like 4 (YM2), CD30 and Immunoglobulin in LMP1 Induced Inflammation Associated Carcinogenesis

Krause, S.A., Xu, H., Gray, J.V. (2008) The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae Eukaryotic Cell, 7, pp. 1880-1887. (doi: 10.1128/EC.00222-08)

Jenkins, G. (2008) Environmental regulation of flavonoid biosynthesis CABI

Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A., Gray, J.V., Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa Journal of Cell Science, 121, pp. 2612-2619. (doi: 10.1242/jcs.033084)

Ciosi, M., Miller, N.J., Kim, K.S., Giordano, R., Estoup, A., Guillemaud, T. (2008) Invasion of Europe by the western corn rootworm, Diabrotica virgifera virgifera: multiple transatlantic introductions with various reductions of genetic diversity Molecular Ecology, 17, pp. 3614-3627. (doi: 10.1111/j.1365-294X.2008.03866.x)

Kamleh, M.A., Hobani, Y., Dow, J.A.T., Watson, D.G. (2008) Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry FEBS Letters, 582, pp. 2916-2922. (doi: 10.1016/j.febslet.2008.07.029)

Tsimbouri, P., Chiou, Y.-C., Wilson, J.B. (2008) EBERs the Small Viral Non-coding RNAs are Tumourigenic and Disturb the Interferon Response in Vivo

Mouw, K.W., Rowland, S.-J., Gajjar, M.M., Boocock, M.R., Stark, W.M., Rice, P.A. (2008) Architecture of a serine recombinase-DNA regulatory complex Molecular Cell, 30, pp. 145-155. (doi: 10.1016/j.molcel.2008.02.023)

MacDonald, A.I., Lu, Y., Kilbride, E.A., Akopian, A., Colloms, S.D. (2008) PepA and ArgR do not regulate Cre recombination at the bacteriophage P1 loxP site Plasmid, 59, pp. 119-126. (doi: 10.1016/j.plasmid.2007.12.001)

Evans, J.M., Day, J.P., Cabrero, P., Dow, J.A.T., Davies, S.A. (2008) A new role for a classical gene: white transports cyclic GMP Journal of Experimental Biology, 211, pp. 890-899. (doi: 10.1242/jeb.014837)

Papadopoulou, K., Ng, S. S., Ohkura, H., Geymonat, M., Sedgwick, S. G., McInerny, C. J. (2008) Regulation of gene expression during M-G1-phase in fission yeast through Plo1p and forkhead transcription factors Journal of Cell Science, 121, pp. 38-47. (doi: 10.1242/jcs.019489)

Jones, M.A., Christie, J.M. (2008) Phototropin receptor kinase activation by blue light Plant Signaling and Behavior, 3, pp. 44-46. (doi: 10.4161/psb.3.1.4848)

Tsimbouri, P., Al-Sheikh, Y., Drotar, M. E., Cushley, W., Wilson, J.B. (2008) Epstein-Barr virus nuclear antigen-1 renders lymphocytes responsive to IL-2 but not IL-15 for survival Journal of General Virology, 89, pp. 2821-2832. (doi: 10.1099/vir.0.83296-0)

Cominelli, E., Gusmaroli, G., Allegra, D., Galbiati, M., Wade, H.K., Jenkins, G.I., Tonelli, C. (2008) Expression analyssis of anthocyanin regulatory genes in response to different light qualities in Arabidopsis thaliana Journal of Plant Physiology, 165, pp. 886-894. (doi: 10.1016/j.jplph.2007.06.010)

Sokolovski, S., Hills, A., Gay, R. A., Blatt, M. R. (2008) Functional interaction of the SNARE protein NtSyp121 in Ca2+ channel gating, Ca2+ transients and ABA signalling of stomatal guard cells Molecular Plant, 1, pp. 347-358. (doi: 10.1093/mp/ssm029)

Sullivan, S., Thomson, C. E., Lamont, D. J., Jones, M. A., Christie, J. M. (2008) In Vivo phosphorylation site mapping and functional characterization of Arabidopsis phototropin 1 Molecular Plant, 1, pp. 178-194. (doi: 10.1093/mp/ssm017)

Cloix, C., Jenkins, G.I. (2008) Interaction of the Arabidopsis UV-B-specific signaling component UVR8 with chromatin Molecular Plant, 1, pp. 118-128. (doi: 10.1093/mp/ssm012)

Blatt, M.R. (2008) Ion Transport at the Plant Plasma Membrane Wiley

Bassham, D.C., Blatt, M.R. (2008) SNAREs: Cogs and coordinators in signaling and development Plant Physiology, 147, pp. 1504-1515. (doi: 10.1104/pp.108.121129)

Amtmann, A., Troufflard, S., Armengaud, P. (2008) The effect of potassium nutrition on pest and disease resistance in plants Physiologia Plantarum, 133, pp. 682-691. (doi: 10.1111/j.1399-3054.2008.01075.x)

Sanford, J. L., Mays, T. A., Varian, K. D., Wilson, J.B., Janssen, P. M.L., Rafael-Fortney, J. A. (2008) Truncated CASK does not alter skeletal muscle or protein interactors Muscle and Nerve, 38, pp. 1116-1127. (doi: 10.1002/mus.20993)

Brown, B.A., Jenkins, G.I. (2008) UV-B signaling pathways with different fluence-rate response profiles are distinguished in mature Arabidopsis leaf tissue by requirement for UVR8, HY5, and HYH Plant Physiology, 146, pp. 576-588. (doi: 10.1104/pp.107.108456)


O'Kane, D., Finlay, C., Mooney, A. (2007) The Goose that Laid the Golden Egg – Widening Access & Outreach Funding

Baker, D. A., Meadows, L. A., Wang, J., Dow, J. A.T., Russell, S. (2007) Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster BMC Genomics, 8, pp. 454. (doi: 10.1186/1471-2164-8-454)

Gray, J.V., Krause, S.A. (2007) Identifying in vivo pathways using genome-wide genetic networks Biochemical Society Transactions, 35, pp. 1538-1541. (doi: 10.1042/BST0351538)

Chen, Z.-H., Nimmo, G.A., Jenkins, G.I., Nimmo, H.G. (2007) BHLH32 modulates several biochemical and morphological processes that respond to Pi starvation in Arabidopsis Biochemical Journal, 405, pp. 191-198. (doi: 10.1042/BJ20070102)

Miller, N.J., Ciosi, M., Sappington, T.W., Ratcliffe, S.T., Spencer, J.L., Guillemaud, T. (2007) Genome scan of Diabrotica virgifera virgifera for genetic variation associated with crop rotation tolerance Journal of Applied Entomology, 131, pp. 378-385. (doi: 10.1111/j.1439-0418.2007.01190.x)

Chiou, Y.-C., Tsimbouri, P., Wilson, J.B. (2007) EBER1 – a Small Viral Non-coding RNA is Tumourigenic and Disturbs the Interferon Response in Vivo

Amtmann, A., Armengaud, P. (2007) The role of calcium sensor-interacting protein kinases in plant adaptation to potassium-deficiency: new answers to old questions Cell Research, 17, pp. 483-485. (doi: 10.1038/cr.2007.49)

Repellin, C., Wilson, J. B. (2007) EBER1 – Small but Influential

McLean, A., Wilson, J.B. (2007) Proteome Changes Induced by LMP1 in Early Carcinogenesis

Jones, M. A., Feeney, K. A., Kelly, S. M., Christie, J. M. (2007) Mutational analysis of phototropin 1 provides insights into the mechanism underlying LOV2 signal transmission Journal of Biological Chemistry, 282, pp. 6405-6414. (doi: 10.1074/jbc.M605969200)

Stewart, M.S., Krause, S.A., McGhie, J., Gray, J.V. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway Eukaryotic Cell, 6, pp. 262-270.

Stewart, M.S., Krause, S.A., McGhie, J., Gray, J.V. (2007) Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway Eukaryotic Cell, 6, pp. 262-270. (doi: 10.1128/EC.00188-06)

Briggs, W.R., Tseng, T.S., Cho, H.Y., Swartz, T.E., Sullivan, S., Bogomolni, R.O., Kaiserli, E., Christie, J.M. (2007) Phototropins and their LOV domains: Versatile plant blue-light receptors Journal of Integrative Plant Biology, 49, pp. 4-10. (doi: 10.1111/j.1672-9072.2007.00406.x)

Cho, H.-Y., Tseng, T.S., Kaiserli, E., Sullivan, S., Christie, J.M., Briggs, W.R. (2007) Physiological roles of the light, oxygen, or voltage domains of phototropin 1 and phototropin 2 in Arabidopsis1 Plant Physiology, 143, pp. 517-529. (doi: 10.1104/pp.106.089839)

Yang, J., McCart, C., Woods, D. J., Terhzaz, S., Greenwood, K. G., Ffrench-Constant, R. H., Dow, J. A.T. (2007) A Drosophila systems approach to xenobiotic metabolism Physiological Genomics, 30, pp. 223-231. (doi: 10.1152/physiolgenomics.00018.2007)

Campanoni, P., Sutter, J., Davis, C., Littlejohn, G., Blatt, M. (2007) A generalized method for transfecting root epidermis uncovers endosomal dynamics in Arabidopsis root hairs Plant Journal, 51, pp. 322-330. (doi: 10.1111/j.1365-313X.2007.03139.x)

Sutter, J., Sieben, C., Hartel, A., Eisenach, C., Thiel, G., Blatt, M. (2007) Abscisic acid triggers the endocytosis of the Arabidopsis KAT1 K+ channel and its recycling to the plasma membrane Current Biology, 17, pp. 1396-1402. (doi: 10.1016/j.cub.2007.07.020)

Moran, C., Yang, N., Bailey, M., Tsiokanos, A., Jamurtas, A., MacArthur, D., North, K., Pitsiladis, Y., Wilson, R. (2007) Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks European Journal of Human Genetics, 15, pp. 88-93. (doi: 10.1038/sj.ejhg.5201724)

Archer, H., Evans, J., Leonard, H., Colvin, L., Ravine, D., Christodoulou, J., Williamson, S., Charman, T., Bailey, M., Sampson, J., de Klerk, N., Clarke, A. (2007) Correlation between clinical severity in patients with Rett Syndrome with a p.R168X or p.T158M MECP2 mutation, and the direction and degree of skewing of X-chromosome inactivation Journal of Medical Genetics, 44, pp. 148-152. (doi: 10.1136/jmg.2006.045260)

O'Kane, D., Finlay, C. (2007) Developing Higher Level Skills in Disadvantaged Students – the Step-Up Programme

Lagou, V., Manios, Y., Moran, C., Bailey, M., Grammatikaki, E., Oikonomou, E., Ioannou, E., Moschonis, G., Wilson, R., Pitsiladis, Y. (2007) Developmental changes in adiposity in toddlers and preschoolers in the GENESIS study and associations with the ACE I/D polymorphism International Journal of Obesity, 31, pp. 1052-1060. (doi: 10.1038/sj.ijo.0803605)

Feng, X., Colloms, S.D. (2007) In vitro transposition of ISY100, a bacterial insertion sequence belonging to the Tc1/mariner family Molecular Microbiology, 65, pp. 1432-1443. (doi: 10.1111/j.1365-2958.2007.05842.x)

Veitch, N.J., Ennis, M., McAbney, J.P., Shelbourne, P.F., Monckton, D.G. (2007) Inherited CAG center dot CTG allele length is a major modifier of somatic mutation length variability in Huntington disease DNA Repair, 6, pp. 789-796. (doi: 10.1016/j.dnarep.2007.01.002)

Dow, J. (2007) Integrative physiology, functional genomics and the phenotype gap: a guide for comparative physiologists Journal of Experimental Biology, 210, pp. 1632-1640. (doi: 10.1242/jeb.002691)

Charalambous, C.T., Hannigan, A., Tsimbouri, P., McPhee, G.M., Wilson, J.B. (2007) Latent membrane protein 1-induced EGFR signalling is negatively regulated by TGF prior to neoplasia Carcinogenesis, 28, pp. 1839-1848. (doi: 10.1093/carcin/bgm055)

Campanoni, P., Blatt, M. (2007) Membrane trafficking and polar growth in root hairs and pollen tubes Journal of Experimental Botany, 58, pp. 65-74. (doi: 10.1093/jxb/erl059)

Blatt, M. (2007) Mitochondrial sequestration of BCECF after ester loading in the giant alga Chara australis Protoplasma, 232, pp. 131-136. (doi: 10.1007/s00709-007-0264-9)

Dow, J. (2007) Model organisms and molecular genetics for endocrinology General and Comparative Endocrinology, 153, pp. 3-12. (doi: 10.1016/j.ygcen.2007.01.023)

Vicente, M., Monferrer, L., Poulos, M., Houseley, J., Monckton, D., ODell, K., Swanson, M., Artero, R. (2007) Muscleblind isoforms are functionally distinct and regulate alpha-actinin splicing Differentiation, 75, pp. 427-440. (doi: 10.1111/j.1432-0436.2006.00156.x)

Tyrrell, M., Campanoni, P., Sutter, J., Pratelli, R., Paneque, M., Sokolovski, S., Blatt, M. (2007) Selective targeting of plasma membrane and tonoplast traffic by inhibitory (dominant-negative) SNARE fragments Plant Journal, 51, pp. 1099-1115. (doi: 10.1111/j.1365-313X.2007.03206.x)

Finlay, C., O'Kane, D. (2007) The Vocational Pathway to Higher Education

Hannigan, A., Burchmore, R., Wilson, J. (2007) The optimization of Protocols for Proteome difference gel electrophoresis (DiGE) analysis of Preneoplastic skin Journal of Proteome Research, 6, pp. 3422-3432. (doi: 10.1021/pr0606878)

Jenkins, G., Brown, B. (2007) UV-B perception and signal transduction Blackwell

Kaiserli, E., Jenkins, G.I. (2007) UV-B promotes rapid nuclear translocation of the Arabidopsis UV-B-specific signaling component UVR8 and activates its function in the nucleus Plant Cell, 19, pp. 2662-2673. (doi: 10.1105/tpc.107.053330)

Chintapalli, V. R., Wang, J., Dow, J. A.T. (2007) Using FlyAtlas to identify better Drosophila melanogaster models of human disease Nature Genetics, 39, pp. 715-720. (doi: 10.1038/ng2049)


Buck, V., Ng, S.S., Ruiz-Garcia, A.B., Papadopoulou, K., Bhatti, S., Samuel, J.M., Anderson, M., Millar, J.B.A., McInerny, C.J. (2004) Fkh2p and Sep1p regulate mitotic gene transcription in fission yeast Journal of Cell Science, 117, pp. 5623-5632. (doi: 10.1242/jcs.01473)

Nöllmann, M., He, J., Byron, O., Stark, W. M. (2004) Solution structure of the Tn3 resolvase-crossover site synaptic complex Molecular Cell, 16, pp. 127-137. (doi: 10.1016/j.molcel.2004.09.027)

Al-Sheikh, Y., Wilson, J.B. (2004) Dissecting the Role of EBNA1 Oncogenic Potential in EµEBNA-1 Transgenic Mice

Tsimbouri, P., Drotar, M., Hill, E., Wilson, J.B. (2004) EBNA1 Induces B-cells to Respond to IL-2 Survival Signals

Mclean, A., Wilson, J.B. (2004) LMP1 Transgenic Mice: a Proteomic Analysis

Reppelin, C., Wilson, J.B. (2004) The EBERs: Small but Influential

Charalambous, C., Wilson, J.B. (2004) The Role of LMP1 in Carcinogenesis in Vivo

Breitling, R., Armengaud, P., Amtmann, A., Herzyk, P. (2004) Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments FEBS Letters, 573, pp. 83-92. (doi: 10.1016/j.febslet.2004.07.055)

Gomes-Pereira, M., Fortune, M.T., Ingram, L., McAbney, J.P., Monckton, D.G. (2004) Pms2 is a genetic enhancer of trinucleotide CAG·CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion Human Molecular Genetics, 13, pp. 1815 -1825. (doi: 10.1093/hmg/ddh186)

Gomes-Pereira, M., Monckton, D.G. (2004) Chemically induced increases and decreases in the rate of expansion of a CAG{middle dot}CTG triplet repeat Nucleic Acids Research, 32, pp. 2865 -2872. (doi: 10.1093/nar/gkh612)

Nöllmann, M., Stark, W. M., Byron, O. (2004) Low-resolution reconstruction of a synthetic DNA Holliday junction Biophysical Journal, 86, pp. 3060-3069. (doi: 10.1016/S0006-3495(04)74355-6)

Breitling, R., Amtmann, A., Herzyk, P. (2004) Iterative Group Analysis (iGA): A simple tool to enhance sensitivity and facilitate interpretation of microarray experiments BMC Bioinformatics, 5,

Stevenson, D., Charalambous, C., Wilson, J.B. (2004) The Paradoxical Role of EBV LMP1 in Carcinogenesis

O'Donnel, M.A., Stevenson, D., Drotar, M., Wilson, J.B. (2004) The Role of EBV LMP1 and LMP2 in B-cell Lymphoma

Cunliffe, L., White, S., McInerny, C.J. (2004) DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe Molecular Genetics and Genomics, 271, pp. 60-71. (doi: 10.1007/s00438-003-0956-6)

Martorell, L., Gamez, J., Cayuela, M.L., Gould, F.K., McAbney, J.P., Ashizawa, T., Monckton, D.G., Baiget, M. (2004) Germline mutational dynamics in myotonic dystrophy type 1 males: Allele length and age effects Neurology, 62, pp. 269 -274.

Gray, J., Petsko, G., Johnston, G., Ringe, D., Singer, R., Werner-Washburne, M. (2004) "Sleeping beauty": Quiescence in Saccharomyces cerevisiae Microbiology and Molecular Biology Reviews, 68, pp. 187-+. (doi: 10.1128/MMBR.68.2.187-206.2004)

Cabrero, P., Pollock, V., Davies, S., Dow, J. (2004) A conserved domain of alkaline phosphatase expression in the Malpighian tubules of dipteran insects Journal of Experimental Biology, 207, pp. 3299-3305. (doi: 10.1242/jeb.01156)

Pratelli, J., Sutter, J., Blatt, M. (2004) A new catch in the SNARE Trends in Plant Science, 9, pp. 187-195. (doi: 10.1016/j.tplants.2004.02.007)

Burke, M., Arnold, P., He, J., Wenwieser, S., Rowland, S., Boocock, M., Stark, W. (2004) Activating mutations of Tn3 resolvase marking interfaces important in recombination catalysis and its regulation Molecular Microbiology, 51, pp. 837-948. (doi: 10.1046/j.1365-2958.2003.03831.x)

Gomes-Pereira, M., Bidichandani, S. I., Monckton, D. G. (2004) Analysis of unstable triplet repeats using small-pool polymerase chain reaction Methods in Molecular Biology, pp. 61-76. (doi: 10.1385/1-59259-804-8:061)

McInerny, C. (2004) Cell cycle-regulated transcription in fission yeast Biochemical Society Transactions, 32, pp. 967-972.

Gomes-Pereira, M., Monckton, D. (2004) Chemically induced increases and decreases in the rate of expansion of a CAG center dot CTG triplet repeat Nucleic Acids Research, 32, pp. 2865-2872. (doi: 10.1093/nar/gkh612)

Pollock, V., McGettigan, J., Cabrero, P., Maudlin, I., Dow, J., Davies, S. (2004) Conservation of capa peptide-induced nitric oxide signalling in Diptera Journal of Experimental Biology, 207, pp. 4135-4145. (doi: 10.1242/jeb.01255)

Gourlay, S., Colloms, S. (2004) Control of Cre recombination by regulatory elements from Xer recombination systems Molecular Microbiology, 52, pp. 53-65. (doi: 10.1111/j.1365-2958.2003.03962.x)

Broderick, K., Kean, L., Dow, J., Pyne, N., Davies, S. (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila Journal of Biological Chemistry, 279, pp. 8159-8168. (doi: 10.1074/jbc.M304679200)

Coolbaugh-Murphy, M., Maleki, A., Ramagli, L., Frazier, M., Lichtiger, B., Monckton, D.G., Siciliano, M.J., Brown, B.W. (2004) Estimating mutant microsatellite allele frequencies in somatic cells by small-pool PCR Genomics, 84, pp. 419 -430. (doi: 10.1016/j.ygeno.2004.03.007)

Wang, J., Kean, L., Yang, J., Allan, A., Davies, S., Herzyk, P., Dow, J. (2004) Function-informed transcriptome analysis of Drosophila renal tubule Genome Biology, 5,

Radford, J.H.C., Terhzaz, S., Cabrero, P., Davies, S.A., Dow, J.A.T. (2004) Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor Journal of Experimental Biology, 207, pp. 4573-4586. (doi: 10.1242/jeb.01317)

Martorell, L., Gamez, J., Cayuela, M., Gould, F., McAbney, J., Ashizawa, T., Monckton, D., Baiget, M. (2004) Germline mutational dynamics in myotonic dystrophy type 1 males - Allele length and age effects Neurology, 62, pp. 269-274.

Breitling, R., Amtmann, A., Herzyk, P. (2004) Graph-based iterative Group Analysis enhances microarray interpretation BMC Bioinformatics, 5, (doi: 10.1186/1471-2105-5-100)

Colloms, S. D. (2004) Leucyl aminopeptidase PepA Elsevier

Collin, E., Rusanen, M., Ackzell, L., Bohnens, J., Aguiar, D.A., Diamandis, S., Franke, A., Gil, L., Harvengt, L., Hollingsworth, P., Jenkins, G., Meier-Dinkel, A., Mittempergher, L., Musch, B., Nagy, L., Paques, M., Pinon, J., Piou, D., Rotach, P., Santini, A., Vanden, A., Wolf, H. (2004) Methods and progress in the conservation of elm genetic resources in Europe Investigacion Agraria: Sistemas y Recursos Forestales, 13, pp. 261-272.

Monckton, D., Ashizawa, T. (2004) Molecular aspects of mytonic dystrophy: our current understanding Oxford University Press

Gomes-Pereira, M., Monckton, D. G. (2004) Mouse tissue culture models of unstable triplet repeats Methods in Molecular Biology, pp. 215-227. (doi: 10.1385/1-59259-804-8:215)

Harper, P.S., Monckton, D.G. (2004) Myotonic dystrophy McGraw-Hill

Sokolovski, S., Blatt, M. (2004) Nitric oxide block of outward-rectifying K+ channels indicates direct control by protein nitrosylation in guard cells Plant Physiology, 136, pp. 4275-4284. (doi: 10.1104/pp.104.050344)

Amtmann, A., Armengaud, P., Breitling, R., Herzyk, P. (2004) Recent advances in using microarray technology to study the role of hormonal control in plant responses to abiotic stress Acta Physiologiae Plantarum, 26, pp. 92-92.

Torrie, L., Radford, J., Southall, T., Kean, L., Dinsmore, A., Davies, S., Dow, J. (2004) Resolution of the insect ouabain paradox Proceedings of the National Academy of Sciences of the United States of America, 101, pp. 13689-13693. (doi: 10.1073/pnas.0403087101)

Sullivan, S., Jenkins, G., Nimmo, H. (2004) Roots, cycles and leaves. Expression of the phosphoenolpyruvate carboxylase kinase gene family in soybean Plant Physiology, 135, pp. 2078-2087. (doi: 10.1104/pp.104.042762)

MacPherson, M., Broderick, K., Graham, S., Day, J., Houslay, M., Dow, J., Davies, S. (2004) The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase Journal of Experimental Biology, 207, pp. 2769-2776. (doi: 10.1242/jeb.01086)

Armengaud, P., Breitling, R., Amtmann, A. (2004) The potassium-dependent transcriptome of Arabidopsis reveals a prominent role of jasmonic acid in nutrient signaling Plant Physiology, 136, pp. 2556-2576. (doi: 10.1104/pp.104.046482)

Volkov, V., Wang, B., Dominy, P., Fricke, W., Amtmann, A. (2004) Thellungiella halophila, a salt-tolerant relative of Arabidopsis thaliana, possesses effective mechanisms to discriminate between potassium and sodium Plant Cell and Environment, 27, pp. 1-14.


Cabrero, P., Radford, J., Broderick, K., Costes, L., Veenstra, J., Spana, E., Davies, S., Dow, J. (2002) The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP Journal of Experimental Biology, 205, pp. 3799-3807.

Charalambous, C., Wilson, J.B. (2002) Dissecting the Role of LMP1 Signalling in Epithelial Cells in Vivo

Anderson, M., Ng, S.S., Marchesi, V., MacIver, F.H., Stevens, F.E., Riddell, T., Glover, D.M., Hagan, I.M., McInerny, C.J. (2002) plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle EMBO Journal, 21, pp. 5745-5755. (doi: 10.1093/emboj/cdf564)

Dabbagh, N., Wilson, J.B. (2002) Is DNA Vaccination a Viable Approach in the Treatment of EBV Associated Tumours?

Abbruzzese, A., Costanzi Porrini, S., Mariani, B., Gould, F.K., McAbney, J.P., Monckton, D.G., Ashizawa, T., Giacanelli, M. (2002) Instability of a premutation allele in homozygous patients with myotonic dystrophy type 1 Annals of Neurology, 52, pp. 435 -441. (doi: 10.1002/ana.10304)

Tsimbouri, P., Wilson, J.B. (2002) The Action of EBNA1 as an Oncogene in Vivo

MacDiarmid, J., Stevenson, D., Wilson, J.B. (2002) The Paradoxical Role of LMP1 in Carcinogenesis

Zhang, Y., Monckton, D.G., Siciliano, M.J., Connor, T.H., Meistrich, M.L. (2002) Detection of radiation and cyclophosphamide-induced mutations in individual mouse sperm at a human expanded trinucleotide repeat locus transgene Mutation Research (Genetic Toxicology and Environmental Mutagenesis), 516, pp. 121 -138. (doi: 10.1016/S1383-5718(02)00035-9)

Fontaine, V., Hartwell, J., Jenkins, G., Nimmo, H. (2002) Arabidopsis thaliana contains two phosphoenolpyruvate carboxylase kinase genes with different expression patterns Plant, Cell and Environment, 25, pp. 115-122. (doi: 10.1046/j.0016-8025.2001.00805.x)

Bregu, M., Sherratt, D.J., Colloms, S.D. (2002) Accessory factors determine the order of strand exchange in Xer recombination at psi EMBO Journal, 21, pp. 3888-3897. (doi: 10.1093/emboj/cdf379)

Zhang, Y., Monckton, D., Siciliano, M.J., Connor, T.H., Meistrich, M.L. (2002) Age and insertion site dependence of repeat number instability of a human DM1 transgene in individual mouse sperm Human Molecular Genetics, 11, pp. 791-798. (doi: 10.1093/hmg/11.7.791)

Rayner, T., Gray, J., Thorner, J. (2002) Direct and novel regulation of cAMP-dependent protein kinase by Mck1p, a yeast glycogen synthase kinase-3 Journal of Biological Chemistry, 277, pp. 16814-16822. (doi: 10.1074/jbc.M112349200)

Brown, J., He, J., Sherratt, D., Stark, W., Boocock, M. (2002) Interactions of protein complexes on supercoiled DNA: The mechanism of selective synapsis by Tn3 resolvase Journal of Molecular Biology, 319, pp. 371-383. (doi: 10.1016/S0022-2836(02)00309-1)

Piazza, P., Procissi, A., Jenkins, G., Tonelli, C. (2002) Members of the c1/pl1 regulatory gene family mediate the response of maize aleurone and mesocotyl to different light qualities and cytokinins Plant Physiology, 128, pp. 1077-1086.

Trotter, E., Kao, C., Berenfeld, L., Botstein, D., Petsko, G., Gray, J. (2002) Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae Journal of Biological Chemistry, 277, pp. 44817-44825. (doi: 10.1074/jbc.M204686200)

Timchenko, L., Tapscott, S., Cooper, T., Monckton, D. (2002) Myotonic dystrophy: Discussion of molecular basis Triple Repeat Diseases of the Nervous Systems, 516, pp. 27-45.

Hartwell, J., Nimmo, G., Wilkins, M., Jenkins, G., Nimmo, H. (2002) Probing the circadian control of phosphoenolpyruvate carboxylase kinase expression in Kalanchoe fedtschenkoi Functional Plant Biology, 29, pp. 663-668. (doi: 10.1071/PP01208)

Kohler, B., Blatt, M. (2002) Protein phosphorylation activates the guard cell Ca2+ channel and is a prerequisite for gating by abscisic acid Plant Journal, 32, pp. 185-194.

Rowland, S., Stark, W., Boocock, M. (2002) Sin recombinase from Staphylococcus aureus: synaptic complex architecture and transposon targeting Molecular Microbiology, 44, pp. 607-619.

He, J., McIlwraith, M., Burke, M., Boocock, M., Stark, W. (2002) Synapsis of Tn3 recombination sites: Unpaired sites destabilize synapses by a partner exchange mechanism Journal of Molecular Biology, 319, pp. 385-393. (doi: 10.1016/S0022-2836(02)00310-8)

Radford, J., Davies, S., Dow, J. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles Journal of Biological Chemistry, 277, pp. 38810-38817. (doi: 10.1074/jbc.M203694200)

Nesi, N., Debeaujon, I., Jond, C., Stewart, A., Jenkins, G., Caboche, M., Lepiniec, L. (2002) The TRANSPARENT TESTA16 locus encodes the ARABIDOPSIS BSISTER MADS domain protein and is required for proper development and pigmentation of the seed coat Plant Cell, 14, pp. 2463-2479. (doi: 10.1105/tpc.004127)

Geelen, D., Leyman, B., Batoko, H., Di Sansabastiano, G., Moore, I., Blatt, M. (2002) The abscisic acid-related SNARE homolog NtSyr1 contributes to secretion and growth: Evidence from competition with its cytosolic domain Plant Cell, 14, pp. 387-406. (doi: 10.1105/tpc.010328)

Krause, S.A., Gray, J.V. (2002) The protein kinase C pathway is required for viability in quiescence in Saccharomyces cerevisiae Current Biology, 12, pp. 588-593.

Blatt, M. (2002) Toward understanding vesicle traffic and the guard cell model New Phytologist, 153, pp. 405-413.

Kean, L., Cazenave, W., Costes, L., Broderick, K.E., Graham, S., Pollock, V.P., Davies, S.A., Veenstra, J.A., Dow, J.A.T. (2002) Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 282, pp. R1297-R1307. (doi: 10.1152/ajpregu.00584.2001)

Tsimbouri, P., Drotar, M.E., Coy, J.L., Wilson, J.B. (2002) bcl-x(L) and RAG genes are induced and the response to IL-2 enhanced in E mu EBNA-1 transgenic mouse lymphocytes Oncogene, 21, pp. 5182-5187. (doi: 10.1038/sj.onc.1205490)


Ng, S.S., Anderson, M., White, S., McInerny, C.J. (2001) mik1+ G1-S transcription regulates mitotic entry in fission yeast FEBS Letters, 503, pp. 131-134. (doi: 10.1016/S0014-5793(01)02720-X)

Nimmo, H.G., Fontaine, V., Hartwell, J., Jenkins, G.I., Nimmo, G.A., Wilkins, M.B. (2001) PEP carboxylase kinase is a novel protein kinase controlled at the level of expression New Phytologist, 151, pp. 91-97. (doi: 10.1046/j.1469-8137.2001.00155.x)

Winchester, C., Wilson, J.B. (2001) Mouse Models of CASK Disruption

Gomes-Pereira, M., Fortune, M.T., Monckton, D.G. (2001) Mouse tissue culture models of unstable triplet repeats: in vitro selection for larger alleles, mutational expansion bias and tissue specificity, but no association with cell division rates Human Molecular Genetics, 10, pp. 845 -854.

Hamilton, D. W.A., Hills, A., Blatt, M. R. (2001) Extracellular Ba2+ and voltage interact to gate Ca2+ channels at the plasma membrane of stomatal guard cells FEBS Letters, 491, pp. 99-103. (doi: 10.1016/S0014-5793(01)02176-7)

Hollies, C.R., Monckton, D.G., Jeffreys, A.J. (2001) Attempts to detect retrotransposition and de novo deletion of Alus and other dispersed repeats at specific loci in the human genome European Journal of Human Genetics, 9, pp. 143 -146.

Murnaghan, S., Wilson, J.B. (2001) CASK in Palate Development

Martorell, L., Monckton, D.G., Sanchez, A., de Munain, A.L., Baiget, M. (2001) Frequency and stability of the myotonic dystrophy type 1 premutation Neurology, 56, pp. 328 -335.

Sarkis, G., Murley, L., Leschziner, A., Boocock, M., Stark, W., Grindley, N. (2001) A model for the gamma delta resolvase synaptic complex Molecular Cell, 8, pp. 623-631.

Giannakou, M., Dow, J. (2001) Characterization of the Drosophila melanogaster alkali-metal/proton exchanger (NHE) gene family Journal of Experimental Biology, 204, pp. 3703-3716.

Wilson, J.B., Drotar, M.E. (2001) Considerations in generating transgenic mice: DNA, RNA, and protein extractions from tissues–rapid and effective blotting The Humana Press Inc.

(2001) Epstein-Barr Virus Protocols 174, (doi: 10.1385/1592592279)

Curran, J., Laverty, F., Campbell, D., Macdiarmid, J., Wilson, J. (2001) Epstein-Barr virus encoded latent membrane protein-1 induces epithelial cell proliferation and sensitizes transgenic mice to chemical carcinogenesis Cancer Research, 61, pp. 6730-6738.

Wade, H., Bibikova, T., Valentine, W., Jenkins, G. (2001) Interactions within a network of phytochrome, cryptochrome and UV-B phototransduction pathways regulate chalcone synthase gene expression in Arabidopsis leaf tissue Plant Journal, 25, pp. 675-685.

Blatt, M. (2001) Localization and control of expression of Nt-Syr1, a tobacco SNARE protein. Plant Journal, 24, pp. 369-381. (doi: 10.1046/j.1365-313x.2000.00886.x)

MacPherson, M., Pollock, V., Broderick, K., Kean, L., OConnell, F., Dow, J., Davies, S. (2001) Model organisms: New insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster American Journal of Physiology: Cell Physiology, 280, pp. C394-C407.

Gomes-Pereira, M., Fortune, M., Monckton, D. (2001) Mouse tissue culture models of unstable triplet repeats: in vitro selection for larger alleles, mutational expansion bias and tissue specificity, but no association with cellDivision rates Human Molecular Genetics, 10, pp. 845-854.

Amtmann, A. (2001) Phylogenetic relationships within cation transporter families of Arabidopsis Plant Physiology, 126, pp. 1646-1667. (doi: 10.1104/pp.126.4.1646)

Trotter, E.W., Berenfeld, L., Krause, S.A., Petsko, G.A., Gray, J.V. (2001) Protein misfolding and temperature up-shift cause G(1) arrest via a common mechanism dependent on heat shock factor in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America, 98, pp. 7313-7318. (doi: 10.1073/pnas.121172998)

Kargul, J., Gansel, X., Tyrrell, M., Sticher, L., Blatt, M. R. (2001) Protein-binding partners of the tobacco syntaxin NtSyr1 FEBS Letters, 508, pp. 253-258. (doi: 10.1016/S0014-5793(01)03089-7)

Tsimbouri, P., O'Donnell, M.A., Wilson, J.B. (2001) Selection and enrichment of B cells from lymphoid tissues The Humana Press Inc.

Macdiarmid, J., Wilson, J.B. (2001) Separation of epidermal tissue from underlying dermis and primary keratinocyte culture The Humana Press Inc.

Dow, J., Davies, S. (2001) The Drosophila melanogaster malpighian tubule Advances in Insect Physiology, 28, pp. 1-83.

Stewart, A., Chapman, W., Jenkins, G., Graham, I., Martin, T., Crozier, A. (2001) The effect of nitrogen and phosphorus deficiency on flavonol accumulation in plant tissues Plant Cell and Environment, 24, pp. 1189-1197.

White, S., Khaliq, F., Sotiriou, S., McInerny, C.J. (2001) The role of DSC1 components cdc10+, rep1+ and rep2+ in MCB gene transcription at the mitotic G1-S boundary in fission yeast Current Genetics, 40, pp. 251-259. (doi: 10.1007/s002940100248)

Amtmann, A. (2001) The wheat cDNA LCT1 generates hypersensitivity to sodium in a salt-sensitive yeast strain Plant Physiology, 126, pp. 1061-1071. (doi: 10.1104/pp.126.3.1061)

Jenkins, G., Long, J., Wade, H., Shenton, M., Bibikova, T. (2001) UV and blue light signalling: pathways regulating chalcone synthase gene expression in Arabidopsis New Phytologist, 151, pp. 121-131.

Molecular genetics research within the School of Molecular Biosciences ranges from:

  • the analysis of DNA sequence and epigenetic variation in health and disease, through structural analysis of DNA -protein interactions to genomic approaches
  • to the analysis of gene function within cells, organisms and populations & the development of genetics-informed therapeutic approaches.

An additional focus is on gene-environment interactions, including nutrition and the microbiome in animals, and temperature, light and salinity in plants. Research advances are impacting in a number of areas, most notably to problems in healthy ageing, food security and synthetic biology.

Topics covered within the theme include:

  • site specific recombination and transposition
  • inherited human disease and variation
  • animal models of human disease and development of molecular therapies
  • insect integrative physiology and ageing
  • epigenetic and nuclear organisational responses to environmental stimuli in plants

Research within the Molecular Genetics theme complements genetic research ongoing elsewhere across the College. We also maintain strong links with the West of Scotland Genetic Services at the Queen Elizabeth University Hospital Glasgow. Our work is very well supported by next-generation DNA sequencing, single-cell and spatial transcriptomics, and other multi-omic systems approaches accessed through Glasgow Polyomics. Molecular Genetics staff also make major research-led teaching contributions to our highly rated BSc Honours degree in Genetics and a variety of masters programmes.